Our laboratory works in the areas of genome-scale biology, bioinformatics, and human genetics. We apply advanced computational and quantitative analysis to genome-scale data in pursuit of the most interesting and important biological questions.
In human genetics, we use new DNA sequencing technologies to investigate mutations that occur in tumors as they become more aggressive and to detect rare germline mutations that might cause neurological disorders.
In genome-scale-biology and bioinformatics, we develop approaches for analyzing and interpreting high-dimensional, genome-scale data sets, such as those generated by gene-expression arrays and metabolic profiling. Technologies for generating genome-scale data are improving exponentially, and strategies that incorporate these data are becoming increasingly central in biological research. Our goal is to use these data to gain new insights into biological processes in health and in disease.